This is, in fact, 2 manuscripts from different dates that have been bound together. The first, Parts 1 and 2, date from the 12th-13th centuries. The second, Parts 3 and 4, are a little later, dating from the 13th-14th centuries. All were probably written in France.
Art 1 (ff.1-66v): This is a second copy of Circa Instans, which can also be found in MS10. There are many marginalia in a later hand, probably an English writer in the 14th century, who may be Simon Bredon, a fellow of Merton College in that period.
Art 2 (ff. 67-123v): Part of the 'Practica' of Roger de Baron, which can also be found in MS15.
Art 3 (ff.131-167): The second part of Isaac Judeus' work on remedies and ailments. Originally written around the start of the 10th century, by the time of this copy, the text had entered the medical curriculum of European medical schools.
Art 4 (ff.168-213): The firstpart of Isaac Judeus' work on remedies and ailments.